Anti-NOTCH1 Polyclonal Antibody
品牌：solarbio | 货号：K007611P
| 英文名称 | Anti-NOTCH1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | hN1;TAN1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Rat |
| 蛋白分子量 | 273kDa |
| Gene ID | 4851 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human NOTCH1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human NOTCH1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P46531 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. |