Anti-TNFSF11 Polyclonal Antibody
品牌：solarbio | 货号：K008348P
| 英文名称 | Anti-TNFSF11 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ODF;OPGL;sOdf;CD254;OPTB2;RANKL;TNLG6B;TRANCE;hRANKL2 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:30-150. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 36kDa |
| Gene ID | 8600 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human TNFSF11 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human TNFSF11 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O14788 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |