Anti-RPSA Polyclonal Antibody
品牌：solarbio | 货号：K106996P
| 英文名称 | Anti-RPSA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 37/67 kDa laminin receptor;37LRP;40S ribosomal protein SA;67 kDa laminin receptor;67LR;LAMBR;Laminin receptor;Laminin receptor 1;LamR;LAMR1;LBP/p40;LRP;LRP/LR;NEM/1CHD4;p40;ribosomal protein SA;RPSA |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 33kDa |
| Gene ID | 3921 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human RPSA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human RPSA |
| Subcellular Locations | Cytoplasm Nucleus Cell membrane |
| Swiss Prot | P08865 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. |