Anti-MADH7 Polyclonal Antibody
品牌:solarbio | 货号:K106646P
英文名称 |
Anti-MADH7 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CRCS3;MADH7;MADH8;Hsmad7;MAD homolog 8 |
应用 |
IHC |
稀释比例 |
IHC 1:50-200. |
交叉反应 |
Human |
蛋白分子量 |
46kDa |
Gene ID |
4092 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human MADH7 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human MADH7 |
Subcellular Locations |
Nucleus |
Swiss Prot |
O15105 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |