Anti-MADH7 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-MADH7 Polyclonal Antibody

品牌:solarbio | 货号:K106646P

英文名称 Anti-MADH7 Polyclonal Antibody
宿主 Rabbit
别名 CRCS3;MADH7;MADH8;Hsmad7;MAD homolog 8
应用 IHC
稀释比例 IHC 1:50-200.
交叉反应 Human
蛋白分子量 46kDa
Gene ID 4092
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human MADH7
性状 液体
Public Immunogen Range A synthetic peptide of human MADH7
Subcellular Locations Nucleus
Swiss Prot O15105
克隆类型 Polyclonal Antibody
背景资料 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.