Anti-APOB Polyclonal Antibody
品牌：solarbio | 货号：K007383P
| 英文名称 | Anti-APOB Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FLDB;LDLCQ4 |
| 应用 | IHC |
| 稀释比例 | IHC 1:15-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 516kDa |
| Gene ID | 338 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human APOB |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human APOB |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P04114 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. |