Anti-COL4A3 Polyclonal Antibody
品牌：solarbio | 货号：K107032P
| 英文名称 | Anti-COL4A3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | collagen alpha-3(IV) chain,Tumstatin |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 蛋白分子量 | 162/158/143/135kDa |
| Gene ID | 1285 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human COL4A3 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human COL4A3 |
| Subcellular Locations | Cell membrane?Extracellular matrixCytoplasm? |
| Swiss Prot | Q01955 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. |