Anti-FADD Polyclonal Antibody
品牌：solarbio | 货号：K008372P
| 英文名称 | Anti-FADD Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GIG3;MORT1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:1000-5000. IHC 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 23kDa |
| Gene ID | 8772 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FADD |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FADD |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q13158 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |