Anti-ACTN4 Polyclonal Antibody
品牌：solarbio | 货号：K107010P
| 英文名称 | Anti-ACTN4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ACTININ-4,FSGS,FSGS1,alpha-actinin-4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:8000-12000. IHC 1:100-300. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 105/80/60kDa |
| Gene ID | 81 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human ACTN4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human ACTN4 |
| Subcellular Locations | Nucleus? |
| Swiss Prot | O43707 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. |