Anti-MAPKBP1 Polyclonal Antibody
品牌：solarbio | 货号：K003452P
| 英文名称 | Anti-MAPKBP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | JNKBP-1;JNKBP1;NPHP20 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-500. IHC 1:50-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 164kDa |
| Gene ID | 23005 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MAPKBP1 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MAPKBP1 |
| Subcellular Locations | Cytoskeleton Nucleus |
| Swiss Prot | O60336 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-β-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFκB (nuclear factor κ-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. |