Anti-PSMC4 Polyclonal Antibody
品牌:solarbio | 货号:K003374P
英文名称 |
Anti-PSMC4 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
MIP224;RPT3;S6;TBP-7;TBP7 |
应用 |
WB IHC IF |
稀释比例 |
WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
交叉反应 |
Human Mouse |
蛋白分子量 |
47kDa |
Gene ID |
5704 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human PSMC4 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human PSMC4 |
Subcellular Locations |
Cytoplasm Nucleus |
Swiss Prot |
P43686 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson’s disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |