Anti-TLR3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-TLR3 Polyclonal Antibody

品牌:solarbio | 货号:K008081P

英文名称 Anti-TLR3 Polyclonal Antibody
宿主 Rabbit
别名 CD283;IIAE2
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse
蛋白分子量 104kDa
Gene ID 7098
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human TLR3
性状 液体
Public Immunogen Range Recombinant protein of human TLR3
Subcellular Locations Cytoplasm
Swiss Prot O15455
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.?