Anti-GPX4 Polyclonal Antibody
品牌：solarbio | 货号：K006597P
| 英文名称 | Anti-GPX4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GPx-4;GSHPx-4;MCSP;PHGPx;SMDS;snGPx;snPHGPx |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 25kDa |
| Gene ID | 2879 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant funsion protein containing a sequence corresponding to amino acids 30-197 of human GPX4 (NP_002076.2). |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant funsion protein containing a sequence corresponding to amino acids 30-197 of human GPX4 (NP_002076.2). |
| Subcellular Locations | Cytoplasm Mitochondrion |
| Swiss Prot | P36969 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a ‘moonlighting’ protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3′ UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. |