Anti-Phospho-APP-T668 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-Phospho-APP-T668 Polyclonal Antibody

品牌:solarbio | 货号:K006161P

英文名称 Anti-Phospho-APP-T668 Polyclonal Antibody
宿主 Rabbit
别名 AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Mouse Rat
蛋白分子量 87kDa
Gene ID 351
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A phospho specific peptide corresponding to residues surrounding T668 of human APP
性状 液体
Public Immunogen Range A phospho specific peptide corresponding to residues surrounding T668 of human APP
Subcellular Locations Membrane Single-pass type I membrane protein clathrin-coated pit
Swiss Prot P05067
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.