Anti-FEN1 Polyclonal Antibody
品牌：solarbio | 货号：K106989P
| 英文名称 | Anti-FEN1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DNase IV;FEN 1;FEN1;Flap endonuclease 1;flap structure endonuclease 1;hFEN 1;Maturation factor 1;MF1;RAD2 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 43kDa |
| Gene ID | 2237 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FEN1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FEN1 |
| Subcellular Locations | Nucleus Cytoplasm? |
| Swiss Prot | P39748 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene removes 5′ overhanging flaps in DNA repair and processes the 5′ ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5′ end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. |