Anti-IL12B Polyclonal Antibody
品牌：solarbio | 货号：K106999P
| 英文名称 | Anti-IL12B Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CLMF;CLMF p40;CLMF2;IL 12 subunit p40;IL 12B;IL12B;Interleukin 12 subunit beta;NKSF;NKSF2 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 37kDa |
| Gene ID | 3593 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human IL12B |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human IL12B |
| Subcellular Locations | Secreted?? |
| Swiss Prot | P29460 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. |