Anti-IL12B Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-IL12B Polyclonal Antibody

品牌:solarbio | 货号:K106999P

英文名称 Anti-IL12B Polyclonal Antibody
宿主 Rabbit
别名 CLMF;CLMF p40;CLMF2;IL 12 subunit p40;IL 12B;IL12B;Interleukin 12 subunit beta;NKSF;NKSF2
应用 IHC
稀释比例 IHC 1:50-200.
交叉反应 Human
蛋白分子量 37kDa
Gene ID 3593
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human IL12B
性状 液体
Public Immunogen Range Recombinant protein of human IL12B
Subcellular Locations Secreted??
Swiss Prot P29460
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.