Anti-PPARD Polyclonal Antibody
品牌：solarbio | 货号：K007621P
| 英文名称 | Anti-PPARD Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | FAAR;NUC1;NUCI;NR1C2;NUCII;PPARB |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:50-300. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 50kDa |
| Gene ID | 5467 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human PPARD |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human PPARD |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q03181 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. |