Anti-GCK Polyclonal Antibody
品牌：solarbio | 货号：K007049P
| 英文名称 | Anti-GCK Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GK;GLK;HK4;HHF3;HKIV;HXKP;LGLK;MODY2;FGQTL3 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 52kDa |
| Gene ID | 2645 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GCK |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GCK |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P35557 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |