Anti-Phospho-Rb-S811 Polyclonal Antibody
品牌：solarbio | 货号：K006202P
| 英文名称 | Anti-Phospho-Rb-S811 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | OSRC;PPP1R130;RB;p105-Rb;pRb;pp110 |
| 应用 | WB IF |
| 稀释比例 | WB 1:1000-2000. IF 1:50-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 106kDa |
| Gene ID | 5925 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S811 of human RB |
| 性状 | 液体 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding S811 of human RB |
| Subcellular Locations | Nucleus |
| Swiss Prot | P06400 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |