Anti-CPEB4 (N-term) Polyclonal Antibody
品牌:solarbio | 货号:K006384P
英文名称 |
Anti-CPEB4 (N-term) Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
CPEB4 (N-term) |
应用 |
WB IHC-P |
稀释比例 |
WB 1:1000. IHC 1:50-100. |
交叉反应 |
Human Mouse |
蛋白分子量 |
80kDa |
Gene ID |
|
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
Ig |
免疫原 |
synthetic peptide between 109-137 amino acids |
性状 |
液体 |
Public Immunogen Range |
synthetic peptide between 109-137 amino acids |
Subcellular Locations |
Plasma membrane Endoplasmic reticulum |
Swiss Prot |
Q17RY0 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5′-UUUUUAU-3′) within the mRNA 3′-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). |