Anti-CASR Polyclonal Antibody
品牌：solarbio | 货号：K007286P
| 英文名称 | Anti-CASR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CAR;FHH;FIH;HHC;EIG8;HHC1;NSHPT;PCAR1;GPRC2A;HYPOC1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:50-300. |
| 交叉反应 | Human |
| 蛋白分子量 | 121kDa |
| Gene ID | 846 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CASR |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CASR |
| Subcellular Locations | Cell membrane |
| Swiss Prot | P41180 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. |