Anti-FCGR3A Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-FCGR3A Polyclonal Antibody

品牌:solarbio | 货号:K003411P

英文名称 Anti-FCGR3A Polyclonal Antibody
宿主 Rabbit
别名 CD16;CD16A;FCG3;FCGR3;FCGRIII;FCR-10;FCRIII;FCRIIIA;IGFR3;IMD20
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量 29kDa
Gene ID 2214
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human FCGR3A
性状 液体
Public Immunogen Range A synthetic peptide of human FCGR3A
Subcellular Locations Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot P08637
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.