Anti-AFF1 Polyclonal Antibody
品牌：solarbio | 货号：K004875P
| 英文名称 | Anti-AFF1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AF4;MLLT2;PBM1 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 131kDa |
| Gene ID | 4299 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human AFF1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human AFF1 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P51825 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. |