Anti-TP53 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-TP53 Polyclonal Antibody

品牌:solarbio | 货号:K004223P

英文名称 Anti-TP53 Polyclonal Antibody
宿主 Rabbit
别名 Trp53;TP53;bbl;bfy;bhy;p44;p53;
应用 WB IF
稀释比例 WB 1:500-2000. IF 1:10-100.
交叉反应 Human Mouse Rat
蛋白分子量 44kDa
Gene ID 22059
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of mouse TP53
性状 液体
Public Immunogen Range Recombinant protein of mouse TP53
Subcellular Locations Endoplasmic reticulum Mitochondrion Nucleus
Swiss Prot P02340
克隆类型 Polyclonal Antibody
背景资料 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it’s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.