Anti-PTRH2 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PTRH2 Polyclonal Antibody

品牌:solarbio | 货号:K004551P

英文名称 Anti-PTRH2 Polyclonal Antibody
宿主 Rabbit
别名 BIT1;CFAP37;CGI-147;IMNEPD;PTH;PTH 2;PTH2
应用 WB IHC IF
稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:10-100.
交叉反应 Human Mouse Rat
蛋白分子量 19kDa
Gene ID 51651
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human PTRH2
性状 液体
Public Immunogen Range Recombinant protein of human PTRH2
Subcellular Locations Mitochondrion
Swiss Prot Q9Y3E5
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.