Anti-CERS4 Polyclonal Antibody
品牌：solarbio | 货号：K007757P
| 英文名称 | Anti-CERS4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Trh1;LASS4 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 46kDa |
| Gene ID | 79603 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human CERS4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human CERS4 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9HA82 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis. |