Anti-ACHE Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-ACHE Polyclonal Antibody

品牌:solarbio | 货号:K003494P

英文名称 Anti-ACHE Polyclonal Antibody
宿主 Rabbit
别名 ACEE;ARACHE;N-ACHE;YT
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 68kDa
Gene ID 43
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human ACHE
性状 液体
Public Immunogen Range Recombinant protein of human ACHE
Subcellular Locations Cell junction Cell membrane Extracellular side GPI-anchor Lipid-anchor Nucleus Peripheral membrane protein Secreted synapse
Swiss Prot P22303
克隆类型 Polyclonal Antibody
背景资料 Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.