Anti-ACHE Polyclonal Antibody
品牌:solarbio | 货号:K003494P
英文名称 |
Anti-ACHE Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ACEE;ARACHE;N-ACHE;YT |
应用 |
WB IHC |
稀释比例 |
WB 1:500-2000. IHC 1:50-100. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
68kDa |
Gene ID |
43 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ACHE |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ACHE |
Subcellular Locations |
Cell junction Cell membrane Extracellular side GPI-anchor Lipid-anchor Nucleus Peripheral membrane protein Secreted synapse |
Swiss Prot |
P22303 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. |