Anti-DNASE1 Polyclonal Antibody
品牌：solarbio | 货号：K003399P
| 英文名称 | Anti-DNASE1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DNL1;DRNI |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-100. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 31kDa |
| Gene ID | 1773 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DNASE1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DNASE1 |
| Subcellular Locations | Nucleus envelope Secreted |
| Swiss Prot | P24855 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |