Anti-DFFA Polyclonal Antibody
品牌：solarbio | 货号：K106992P
| 英文名称 | Anti-DFFA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DFF 45;DFF1;DFF45;DFF45/DFFA;DFFA;ICAD;Inhibitor of CAD |
| 应用 | WB IHC |
| 稀释比例 | WB 1:8000-12000. IHC 1:100-300. |
| 交叉反应 | Human |
| 蛋白分子量 | 37kDa |
| Gene ID | 1676 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DFFA |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DFFA |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O00273? |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.? |