Anti-IDE Polyclonal Antibody
品牌：solarbio | 货号：K008171P
| 英文名称 | Anti-IDE Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | INSULYSIN |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:10-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 118kDa |
| Gene ID | 3416 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human IDE |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human IDE |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | P14735 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein’s function are associated with Alzheimer’s disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |