Anti-APITD1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-APITD1 Polyclonal Antibody

品牌:solarbio | 货号:K005741P

英文名称 Anti-APITD1 Polyclonal Antibody
宿主 Rabbit
别名 CENPS;APITD1;CENP-S;FAAP16;MHF1;
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human
蛋白分子量 16kDa
Gene ID 378708
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human APITD1
性状 液体
Public Immunogen Range Recombinant protein of human APITD1
Subcellular Locations Chromosome Nucleus centromere kinetochore
Swiss Prot Q8N2Z9
克隆类型 Polyclonal Antibody
背景资料 This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.