Anti-RAD17 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-RAD17 Polyclonal Antibody

品牌:solarbio | 货号:K003938P

英文名称 Anti-RAD17 Polyclonal Antibody
宿主 Rabbit
别名 CCYC;HRAD17;R24L;RAD17SP;RAD24
应用 WB IF IP
稀释比例 WB 1:500-2000. IF 1:10-100. IP 1:50-200.
交叉反应 Human
蛋白分子量 77kDa
Gene ID 5884
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human RAD17
性状 液体
Public Immunogen Range Recombinant protein of human RAD17
Subcellular Locations Nucleus
Swiss Prot O75943
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.