Anti-RAD17 Polyclonal Antibody
品牌：solarbio | 货号：K003938P
| 英文名称 | Anti-RAD17 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | CCYC;HRAD17;R24L;RAD17SP;RAD24 |
| 应用 | WB IF IP |
| 稀释比例 | WB 1:500-2000. IF 1:10-100. IP 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 77kDa |
| Gene ID | 5884 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human RAD17 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human RAD17 |
| Subcellular Locations | Nucleus |
| Swiss Prot | O75943 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |