Anti-MECP2 Polyclonal Antibody
品牌：solarbio | 货号：K004143P
| 英文名称 | Anti-MECP2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AUTSX3;MRX16;MRX79;MRXS13;MRXSL;PPMX;RS;RTS;RTT |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 52kDa |
| Gene ID | 4204 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human MECP2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human MECP2 |
| Subcellular Locations | Nucleus |
| Swiss Prot | P51608 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. |