Anti-PRKG1 Polyclonal Antibody
品牌：solarbio | 货号：K003422P
| 英文名称 | Anti-PRKG1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AAT8;PKG;PRKG1B;PRKGR1B;cGK;cGK 1;cGK1;cGKI;cGKI-BETA;cGKI-alpha |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 76kDa |
| Gene ID | 5592 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PRKG1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PRKG1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q13976 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. |