Anti-IRAK1BP1 Polyclonal Antibody
品牌：solarbio | 货号：K006776P
| 英文名称 | Anti-IRAK1BP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AIP70;SIMPL |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 29kDa |
| Gene ID | 134728 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human IRAK1BP1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human IRAK1BP1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q5VVH5 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active. |