Anti-TWIST Polyclonal Antibody
品牌:solarbio | 货号:K106441P
英文名称 |
Anti-TWIST Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ACS3;bHLHa38;BPES2;BPES3;CRS;CRS1;CSO;SCS;TWIST |
应用 |
WB |
稀释比例 |
WB 1:3000. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
33kDa |
Gene ID |
7291 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human TWISTprotein |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human TWISTprotein |
Subcellular Locations |
Nucleus |
Swiss Prot |
Q15672 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer |