Anti-TWIST Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-TWIST Polyclonal Antibody

品牌:solarbio | 货号:K106441P

英文名称 Anti-TWIST Polyclonal Antibody
宿主 Rabbit
别名 ACS3;bHLHa38;BPES2;BPES3;CRS;CRS1;CSO;SCS;TWIST
应用 WB
稀释比例 WB 1:3000.
交叉反应 Human Mouse Rat
蛋白分子量 33kDa
Gene ID 7291
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human TWISTprotein
性状 液体
Public Immunogen Range A synthetic peptide of human TWISTprotein
Subcellular Locations Nucleus
Swiss Prot Q15672
克隆类型 Polyclonal Antibody
背景资料 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer