Anti-GCLC Polyclonal Antibody
品牌：solarbio | 货号：K007255P
| 英文名称 | Anti-GCLC Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | GCL;GCS;GLCL;GLCLC |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 73kDa |
| Gene ID | 2729 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human GCLC |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human GCLC |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | P48506 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. |