Anti-MARCH2 Polyclonal Antibody
品牌：solarbio | 货号：K007245P
| 英文名称 | Anti-MARCH2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | RNF172;HSPC240;MARCH-II |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 27kDa |
| Gene ID | 51257 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Full length fusion protein |
| 性状 | 液体 |
| Public Immunogen Range | Full length fusion protein |
| Subcellular Locations | Lysosome Endosome Endoplasmic reticulum |
| Swiss Prot | Q9P0N8 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking. |