Anti-LRP2 Polyclonal Antibody
品牌：solarbio | 货号：K003680P
| 英文名称 | Anti-LRP2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DBS;GP330 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:20-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 522kDa |
| Gene ID | 4036 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human LRP2 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human LRP2 |
| Subcellular Locations | Membrane Single-pass type I membrane protein coated pit |
| Swiss Prot | P98164 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). |