Anti-APP Polyclonal Antibody
品牌：solarbio | 货号：K003616P
| 英文名称 | Anti-APP Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 87kDa |
| Gene ID | 351 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human APP |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human APP |
| Subcellular Locations | Membrane Single-pass type I membrane protein clathrin-coated pit |
| Swiss Prot | P05067 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |