Anti-FURIN Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-FURIN Polyclonal Antibody

品牌:solarbio | 货号:K005253P

英文名称 Anti-FURIN Polyclonal Antibody
宿主 Rabbit
别名 FUR;PACE;PCSK3;SPC1
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse
蛋白分子量 87kDa
Gene ID 5045
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human FURIN
性状 液体
Public Immunogen Range Recombinant protein of human FURIN
Subcellular Locations Cell membrane Golgi apparatus Single-pass type I membrane protein trans-Golgi network membrane
Swiss Prot P09958
克隆类型 Polyclonal Antibody
背景资料 This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.