Anti-IQGAP3 Polyclonal Antibody
品牌：solarbio | 货号：K006775P
| 英文名称 | Anti-IQGAP3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Ras GTPase-activating-like protein IQGAP3 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 185kDa |
| Gene ID | 128239 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human IQGAP3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human IQGAP3 |
| Subcellular Locations | Cytoplasm Cell membrane |
| Swiss Prot | Q86VI3 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |