Anti-IQGAP3 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-IQGAP3 Polyclonal Antibody

品牌:solarbio | 货号:K006775P

英文名称 Anti-IQGAP3 Polyclonal Antibody
宿主 Rabbit
别名 Ras GTPase-activating-like protein IQGAP3
应用 WB
稀释比例 WB 1:200-1000.
交叉反应 Human Mouse
蛋白分子量 185kDa
Gene ID 128239
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human IQGAP3
性状 液体
Public Immunogen Range Recombinant protein of human IQGAP3
Subcellular Locations Cytoplasm Cell membrane
Swiss Prot Q86VI3
克隆类型 Polyclonal Antibody
背景资料 IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.