Anti-IQGAP3 Polyclonal Antibody
品牌:solarbio | 货号:K006775P
英文名称 |
Anti-IQGAP3 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
Ras GTPase-activating-like protein IQGAP3 |
应用 |
WB |
稀释比例 |
WB 1:200-1000. |
交叉反应 |
Human Mouse |
蛋白分子量 |
185kDa |
Gene ID |
128239 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human IQGAP3 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human IQGAP3 |
Subcellular Locations |
Cytoplasm Cell membrane |
Swiss Prot |
Q86VI3 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |