Anti-GRM4 Polyclonal Antibody
品牌：solarbio | 货号：K007941P
| 英文名称 | Anti-GRM4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | mGlu4;GPRC1D;MGLUR4 |
| 应用 | IHC |
| 稀释比例 | IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 102/87/84kDa |
| Gene ID | 2914 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human GRM4 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human GRM4 |
| Subcellular Locations | Membrane |
| Swiss Prot | Q14833 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. |