Anti-CDK2AP1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-CDK2AP1 Polyclonal Antibody

品牌:solarbio | 货号:K003764P

英文名称 Anti-CDK2AP1 Polyclonal Antibody
宿主 Rabbit
别名 DOC1;DORC1;ST19;doc-1;p12DOC-1
应用 WB
稀释比例 WB 1:500-2000.
交叉反应 Human
蛋白分子量 12kDa
Gene ID 8099
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human CDK2AP1
性状 液体
Public Immunogen Range Recombinant protein of human CDK2AP1
Subcellular Locations Cytosol Nucleus
Swiss Prot O14519
克隆类型 Polyclonal Antibody
背景资料 The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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