Anti-CDK2AP1 Polyclonal Antibody
品牌：solarbio | 货号：K003764P
| 英文名称 | Anti-CDK2AP1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | DOC1;DORC1;ST19;doc-1;p12DOC-1 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 12kDa |
| Gene ID | 8099 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human CDK2AP1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human CDK2AP1 |
| Subcellular Locations | Cytosol Nucleus |
| Swiss Prot | O14519 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |