Anti-PCDHA12 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-PCDHA12 Polyclonal Antibody

品牌:solarbio | 货号:K005880P

英文名称 Anti-PCDHA12 Polyclonal Antibody
宿主 Rabbit
别名 PCDH-ALPHA12
应用 WB IHC
稀释比例 WB 1:500-2000. IHC 1:50-100.
交叉反应 Human Mouse Rat
蛋白分子量 102kDa
Gene ID 56137
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 Recombinant protein of human PCDHA12
性状 液体
Public Immunogen Range Recombinant protein of human PCDHA12
Subcellular Locations Cell membrane Single-pass type I membrane protein
Swiss Prot Q9UN75
克隆类型 Polyclonal Antibody
背景资料 This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.