Anti-SIGLEC12 Polyclonal Antibody
品牌：solarbio | 货号：K005892P
| 英文名称 | Anti-SIGLEC12 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | S2V;SIGLECL1;SLG;Siglec-XII |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Mouse |
| 蛋白分子量 | 65kDa |
| Gene ID | 89858 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SIGLEC12 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SIGLEC12 |
| Subcellular Locations | Membrane Single-pass type I membrane protein |
| Swiss Prot | Q96PQ1 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. |