Anti-ACTL6A Polyclonal Antibody
品牌:solarbio | 货号:K003961P
英文名称 |
Anti-ACTL6A Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ACTL6;ARPN-BETA;Arp4;BAF53A;INO80K |
应用 |
WB |
稀释比例 |
WB 1:500-2000. |
交叉反应 |
Human Mouse |
蛋白分子量 |
47kDa |
Gene ID |
86 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ACTL6A |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ACTL6A |
Subcellular Locations |
Nucleus |
Swiss Prot |
O96019 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. |