Anti-DZIP1 Polyclonal Antibody
品牌:solarbio | 货号:K007538P
英文名称 |
Anti-DZIP1 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
DZIP;DZIPt1 |
应用 |
WB IHC |
稀释比例 |
WB 1:200-1000. IHC 1:25-100. |
交叉反应 |
Human |
蛋白分子量 |
99kDa |
Gene ID |
22873 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
A synthetic peptide of human DZIP1 |
性状 |
液体 |
Public Immunogen Range |
A synthetic peptide of human DZIP1 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q86YF9 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
DZIP1(DAZ interacting protein 1) is also known as DZIP or DZIP2 and is a 867 amino acid protein which is expressed as 3 isoforms, designated DZIPb, DZIPt1 and DZIPt2. DZIP1 is localized to testis, oocytes, ovary and fetal brain, as well as in embryonic stem cells and germ cells. In testis, DZIP1 is localized to the nucleus and also shows some cytoplasmic distribution in spermatogonia. DZIP1 belongs to the C2H2-type zinc-finger protein family, and, characteristc of the C2H2-type zinc-finger protein family, DZIP1 contains one C2H2-type zinc-finger region through which it is thought to interact with DAZ, an interaction that promotes spermiogenesis. DZIP1 expression is not found in those afflicted with Sertoli cell-only syndrome (characterized by the absence of germ cells in the testis), suggesting that the lack of DZIP1 may be involved in the pathogenesis of Sertoli cell-only syndrome-induced male sterility |