Anti-DZIP1 Polyclonal Antibody-一抗-抗体-蛋白与免疫

Anti-DZIP1 Polyclonal Antibody

品牌:solarbio | 货号:K007538P

英文名称 Anti-DZIP1 Polyclonal Antibody
宿主 Rabbit
别名 DZIP;DZIPt1
应用 WB IHC
稀释比例 WB 1:200-1000. IHC 1:25-100.
交叉反应 Human
蛋白分子量 99kDa
Gene ID 22873
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG
免疫原 A synthetic peptide of human DZIP1
性状 液体
Public Immunogen Range A synthetic peptide of human DZIP1
Subcellular Locations Cytoplasm
Swiss Prot Q86YF9
克隆类型 Polyclonal Antibody
背景资料 DZIP1(DAZ interacting protein 1) is also known as DZIP or DZIP2 and is a 867 amino acid protein which is expressed as 3 isoforms, designated DZIPb, DZIPt1 and DZIPt2. DZIP1 is localized to testis, oocytes, ovary and fetal brain, as well as in embryonic stem cells and germ cells. In testis, DZIP1 is localized to the nucleus and also shows some cytoplasmic distribution in spermatogonia. DZIP1 belongs to the C2H2-type zinc-finger protein family, and, characteristc of the C2H2-type zinc-finger protein family, DZIP1 contains one C2H2-type zinc-finger region through which it is thought to interact with DAZ, an interaction that promotes spermiogenesis. DZIP1 expression is not found in those afflicted with Sertoli cell-only syndrome (characterized by the absence of germ cells in the testis), suggesting that the lack of DZIP1 may be involved in the pathogenesis of Sertoli cell-only syndrome-induced male sterility