Anti-TRAF6 Polyclonal Antibody
品牌：solarbio | 货号：K008253P
| 英文名称 | Anti-TRAF6 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | RNF85;MGC:3310 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:30-150. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 60kDa |
| Gene ID | 7189 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human TRAF6 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human TRAF6 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q9Y4K3 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. |