Anti-ALS2 Polyclonal Antibody
品牌:solarbio | 货号:K008298P
英文名称 |
Anti-ALS2 Polyclonal Antibody |
宿主 |
Rabbit |
别名 |
ALSJ;PLSJ;IAHSP;ALS2CR6 |
应用 |
IHC |
稀释比例 |
IHC 1:25-100. |
交叉反应 |
Human Mouse Rat |
蛋白分子量 |
184/43/87kDa |
Gene ID |
57679 |
保存 |
Store at -20°C. Avoid freeze / thaw cycles. |
储存液 |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
纯化方法 |
Affinity purification |
亚型 |
IgG |
免疫原 |
Recombinant protein of human ALS2 |
性状 |
液体 |
Public Immunogen Range |
Recombinant protein of human ALS2 |
Subcellular Locations |
Cytoplasm |
Swiss Prot |
Q96Q42 |
克隆类型 |
Polyclonal Antibody |
背景资料 |
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |