Anti-DOK4 Polyclonal Antibody
品牌：solarbio | 货号：K008338P
| 英文名称 | Anti-DOK4 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | IRS5;Docking protein 4 |
| 应用 | IHC |
| 稀释比例 | IHC 1:50-200. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 37kDa |
| Gene ID | 55715 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DOK4 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DOK4 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q8TEW6 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Docking protein 4?is a?protein?that in humans is encoded by the?DOK4?gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis. |